The leading process for desalination in terms of installed capacity and yearly growth is reverse osmosis (RO). The RO membrane processes use semipermeable membranes and applied pressure (on the membrane feed side) to preferentially induce water permeation through the membrane while rejecting salts. Reverse osmosis plant membrane systems typically use less energy than thermal desalination processes. Energy cost in desalination processes varies considerably depending on water salinity, plant size, and process type. At present, the cost of seawater desalination, for example, is higher than traditional water sources, but it is expected that costs will continue to decrease with technology improvements.

The Reverse Osmosis process is not maintenance free. Various factors interfere with efficiency: ionic contamination (calcium, magnesium, etc.); DOC; bacteria; viruses; colloids & insoluble particulates; biofouling and scaling. In extreme cases, the RO membranes are destroyed. To mitigate damage, various pretreatment stages are introduced. Anti-scaling inhibitors include acids and other agents like the organic polymers Polyacrylamide and Polymaleic Acid, Phosphonates and Polyphosphates. Inhibitors for fouling are biocides (as oxidants against bacteria and viruses), like chlorine, ozone, sodium or calcium hypochlorite. At regular intervals, depending on the membrane contamination; fluctuating seawater conditions; or when prompted by monitoring processes, the membranes need to be cleaned, known as emergency or shock-flushing. Flushing is done with inhibitors in a freshwater solution and the system must go offline. This procedure is environmentally risky since contaminated water is diverted into the ocean without treatment.